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A 2013 meta-analysis of more than 92,000 patients found that Xyzal (levocetirizine) worked better than Allegra (fexofenadine) and the prescription drug Clarinex (desloratadine). Xyzal is produced by Sanofi, and Zyrtec is produced by a division of Johnson & Johnson. The way an antihistamine works is by counteracting your body’s response to allergens. Usage Tips 1 Xyzal is an oral antihistamine that works for 24 hrs to relieve symptoms of indoor and outdoor allergies. Histamine can produce symptoms such as a runny nose or hives. Xyzal (levocetirizine dihydrochloride) is an over-the-counter (OTC) histamine H1-receptor antagonist used to relieve symptoms associated with seasonal and perennial allergic rhinitis and to treat uncomplicated skin manifestations of chronic idiopathic hives. 1% is twice daily for children 2 years and older. 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